To explore the influence of GCs on COX-2 gene expression in activated T cells, we used a human T cell leukemia-derived Jurkat cell line, which does not express a functional endogenous GR (Jurkat), as well as two clones derived from this parental cell line upon stable transfection with expression vectors for a wt version of the rat GR (J-GRwt) or for the GR LS7 mutant (J-GRLS7), as previously described [36,37]. This evidence concerns the gene PTGS2 and T-cell leukemia.