AURKA plays important roles in mitosis and chromosome stability, it is a prognostic marker in CRC [81], it increased the chemosensitivity of colon cancer cells to oxaliplatin by inhibiting the TP53-mediated DNA damage response genes [82], and its expression in CRC liver metastases was associated with poor prognosis [83]. This evidence concerns the gene TP53 and malignant colon neoplasm.