AKT1 and neoplasm: In the HPV- tumor samples, we found that the overabundance of the uncultured bacterium was correlated with the upregulation of the REACTOME_OLFACTORY_SIGNALING_PATHWAY oncogenic pathway (Figure 9A), which has been found to contribute to tumorigenesis and the development of cancers [47], as well as to the increased survival and proliferation of cells through the modulation of MAPK, Rho, and AKT signaling cascades [48,49].