MAPK8 and chronic myelogenous leukemia, BCR-ABL1 positive: For example, ST2 activation of the chronic myeloid leukemia cell line (KU812) results in the release of multiple cytokines through the stimulation of NF-κB, JNK, and p38 MAPK, but not ERK1/2; however, IL-13 generation appears not to require JNK or ERK1-2 signals [75].