In periodontitis, in spite of classical (non-surgical) therapies that include antibiotics and anti-inflammatory drugs, which are often not effective, it is pertinent to think that different anti-IL-1βs, such as soluble IL-1R, IL -1RA, and IL-37, could be used in the clinical therapy for these inflammatory diseases [41,42,43]. The gene discussed is IL37; the disease is periodontitis.