AGT and Polydipsia: In this early (two-week evolution) STZ-induced T1DM model we observed (Figure 9): (1) all the characteristic signs of T1DM (polydipsia, polyuria, polyphagia and body weight loss) and increased fecal excretion; (2) increased length, perimeter and weight in the ileum and colon; (3) increased thickness of several histological intestinal layers (less evident in CD) of the ileum and colon, and (4) decreased Ang II-induced smooth muscle contraction (less evident in the DC) associated with altered balance between the function of Ang II receptors.