PLTP and hydrops fetalis: In a similar manner, insulin tolerance test (ITT) displayed no difference under LF, an altered insulin sensitivity for both genotypes under HF and a slightly more pronounced effect in Pltp-KO mice (248.2 ± 21.46 vs. 197.8 ± 14.65 a.u. in WT mice; p = 0.06) (Figure 2B).