Overall, these results showed that the expression of the BRCT domain from LmjPES protein in mammalian cells deregulated mRNA levels of genes (including DTX3L, CPA4, BHLHE41, BMP2, DHRS2, S100A1, PARP9, BMP2, CARD9, DPYD, Dok3, DTX3L, PARP9 and DHRS2) related to cellular processes (such as proliferation and survival) that promote chemoresistance and tumor development. This evidence concerns the gene DPYD and neoplasm.