In this work, we aimed to characterize the physiological and pathophysiological expression features of the SLC15A4/PHT1 gene products in the intestinal epithelial monolayer in the context of responses to stimuli and processes eliciting inflammation of the GI epithelial barrier, and to identify SLC15A4/PHT1 expression and functional significance in the context of inflammatory alterations related to the human IBD etiological framework. Here, SLC15A4 is linked to inflammatory bowel disease.