An increase in the total myocardial collagen content or an increase in the proportion of type I and III collagen will lead to disruption of the normal myocardial fiber network structure, limiting normal expansion and contraction of the myocardial cells, which will result in decreasing myocardial compliance and ejection capacity, increasing myocardial stiffness, impairing myocardial diastolic or systolic function and ultimately heart failure [29]. The gene discussed is SGCG; the disease is heart failure.