In AD mice, knocking down SOX21-AS prevents neuronal oxidative stress and inhibits cell death, through the upregulation of the FZD3–5 (Frizzled receptor 3)/Wnt signaling pathway [77] and given the close relationship between oxidative stress and inflammation [97], SOX21-AS1 can be classified as pro-inflammatory lncRNA. This evidence concerns the gene SOX21 and Alzheimer disease.