GPNMB and melanoma: Experiments in HepG2 cells, melanoma cell lines, normal melanocytes, and hepatic and prostate tissue of ARSB-deficient mice revealed that decline in ARSB was associated with increase in expression of GPNMB (Glycoprotein Nonmetastatic Melanoma Protein B; Glycoprotein (Transmembrane) Nmb; osteoactivin) [14].