Subsequently, deficiency of ARSB was detected in cultured fibroblasts of patients with the Maroteaux-Lamy Syndrome (MLS) [137], and the relationship between inherited deficiency of ARSB and MLS, subsequently identified as Mucopolysaccharidosis (MPS) VI, was clarified in several studies in the 1970s [6,7,8,9,133,136]. This evidence concerns the gene ARSB and mucopolysaccharidosis.