IRS1 and hyperlipidemia: Among the Andiroba-derived limonoids, DAOG (1) has been reported to enhance the brown adipose tissue to improve hyperlipidemia and insulin resistance in diet-induced obese mice and suppress lipid accumulation by reducing glucose transporter (GLUT) 4 expression in adipocytes via insulin receptor substrate (IRS)-1/Akt axis [71,72].