As with adiponectin, leptin receptors are overexpressed in colon cancer cells, suggesting an active communication mediated by this hormone [55], whereby leptin is able to stimulate cell DNA synthesis and growth in colon cancer cells [56,57,58], suggesting that when levels are increased, it is capable of acting as a growth factor via the MAPK and PI3-K pathways [57]. The gene discussed is LEPR; the disease is malignant colon neoplasm.