More specifically, they secrete adipokines (e.g., leptin, adiponectin, resistin, ghrelin) and inflammatory cytokines (e.g., tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), IL-6, IL-12, and IL-23), among others, all of which are particularly relevant to CRC development, and contribute to the characteristic systemic low-grade inflammation associated with visceral obesity [37]. The gene discussed is TNF; the disease is colorectal carcinoma.