IL6 and colorectal carcinoma: Moreover, increased pre-operative levels of serum IL-6 in CRC patients have been found to be predictive of prognosis [64] and associated with two to four times higher risks of overall mortality [63,68,69,70]; furthermore, elevated post-treatment circulating levels have also been linked to a higher risk of all-cause mortality over a 10-year follow-up period [62].