In addition to in vitro results showing that pan-PAD-inhibitor Cl-amidine reduces histone H3 deimination and pro-inflammatory chemokine expression in PD-derived fibroblasts [26], animal studies of acute CNS injury have demonstrated major roles for PADs (highlighting PAD3) and significant neuroprotective effects using pharmacological pan-PAD inhibition [22,23]. This evidence concerns the gene PADI4 and Parkinson disease.