The actions of NF-κB are mediated by IKKB, which phosphorylates the inhibitory complex d NF-κB (IκB), releasing NF-κB, allowing its translocation to the nucleus where it activates its target genes; in this context, it has been observed that the inactivation of genes encoding IKKB keeps NF-κB inactive and eliminates the bowel inflammation and carcinogenesis associated with colitis [235]. This evidence concerns the gene IKBKB and colitis.