NFKB1 and cancer: Currently, it is known that NF-κB is involved in the initiation and progression of some types of tumors in tissues where cancer-related chronic inflammation usually occurs, such as the gastrointestinal tract and liver [235,236]; moreover, deficiencies of its inhibitor TIR8 are related to an increased susceptibility to the development of bowel inflammation and carcinogenesis [237,238].