EIF2S3 and growth hormone secreting pituitary adenoma 1: In the diversity of differentially expressed proteins, the top three pathways were: SRP-dependent cotranslational protein targeting the membrane, peptide chain elongation, and eukaryotic translation elongation by KEGG pathway enrichment, as shown in Figure 1C. Moreover, we found an imbalance in the EIF2 complex in somatotroph adenomas, i.e., increased α/β subunit and reduction in the γ subunit of eIF2.