Firstly, we analyzed the expression of eight CBX family members, namely CBX1/HP1β, CBX2, CBX3/HP1γ, CBX4, CBX5/HP1α, CBX6, CBX7, and CBX8, in selected solid tumors and relevant normal tissues using the TCGA data for liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), pancreatic adenocarcinoma (PAAD), and uterine endometrial carcinoma (UCEC). The gene discussed is CBX3; the disease is pancreatic adenocarcinoma.