Arthritis induction led to high levels of IL-1β, CXCL1 (chemokine (C–X–C motif) ligand 1), IL-6, TNF-α, and VEGF, which were markedly decreased after BPI treatment three-, two-, two-, 15-, and threefold, respectively (Figure 3). The gene discussed is VEGFA; the disease is arthritic joint disease.