The raised inflammatory milieu driven by VSMCPCSK9-EVs was confirmed by the protein expression of phosphorylated form of STAT3 (signal transducer and activator of transcription 3) and SOCS3 (suppressor of cytokine signaling-3), two well-known cell signalling pathways involved in atherosclerosis [21]. The gene discussed is SOCS3; the disease is atherosclerosis.