This analysis revealed four important cellular pathways that were differentially modulated by the HGD including: cell signaling pathways (including MAPK signaling, PI3K-Akt signaling, Rap1 signaling, and VEGF signaling), neurodegenerative diseases (such as Alzheimer’s disease), cell adhesion (including focal adhesion, regulation of actin cytoskeleton, and Adherens junction), and cellular metabolism (such as Adipogenesis and Inositol phosphate metabolism), Figure 3B. Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.