Among the 60 cellular pathways we identified were those involved in the regulation of cell signaling (e.g., insulin signaling), cell adhesion (e.g., focal adhesion), cellular metabolism (e.g., adipogenesis), neurodegenerative diseases (e.g., Alzheimer’s disease), and cellular stress (e.g., oxidative stress and redox pathway), Supplemental Figure S1. The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.