TNF and stroke disorder: Depletion of Arg1+ microglia/macrophages lead to a significant increase in mRNA expression of iNOS for 5.29-fold (from 1.10 ± 0.04 in the stroke-MLs group to 6.92 ± 0.21 in the stroke-MCLs group), IL-1β for 3.03-fold (from 3.39 ± 0.55 in the stroke-MLs group to 13.65 ± 3.39 in the stroke-MCLs group), and TNF-α for 1-fold (from 0.67 ± 0.08 in the stroke-MLs group to 1.34 ± 0.21 in the stroke-MCLs group) (Figure 4B).