Figure 1 shows a schematic illustration of a migratory and invasive glioblastoma cell. The direction of cell movement is accompanied by an increase in expression of Rac1 at the leading edge of the lamellipodia. NDV targets Rac1 at the lamellipodia via macropinocytosis/endocytosis. Following cell entry, NDV targets the cap-dependent translational machinery through the MNK1/2-eIF4E axis [93]. Tumor-selective virus replication then occurs in autophagosomes [56]. F and HN proteins play important roles in virus release and immune cell activation. Oncolysis is exerted by ICD [93]. This evidence concerns the gene RAC1 and neoplasm.