Notably, blockade of CCR5 on g-MDSCs considerably attenuated the expression of lipogenic genes, such as Cd36, Acc-1, Scd-1, and Pgc-1β (Figure 6c,d, compare bars 3 and 4), and the pro-inflammatory gene Il-1β (Figure 6e, compare bar 3 and 4), in hepatocytes under NAFLD microenvironment. Here, CCR5 is linked to metabolic dysfunction-associated steatotic liver disease.