CCR5 and metabolic dysfunction-associated steatotic liver disease: Intriguingly, in the NAFLD microenvironment, although g-MDSCs up-regulated STAT3 expression (Figure 6b, compare bars 5 and 7), null of CCR5 signaling strongly attenuated g-MDSCs’ capability of enhancing STAT3 signaling in hepatocytes (Figure 6b, compare bars 7 and 8).