In a cell model of PD, αSyn significantly increased MHC-II expression, together with IFN-ɣ and IL-16 levels, which were potentiated with CUDC-907 (a dual PI3K and histone deacetylase (HDAC) inhibitor) and TMP-195 (a potent and selective inhibitor of class IIa HDAC) [69]. Here, HDAC9 is linked to Parkinson disease.