In line with this view, we have previously demonstrated the involvement of the lysosomal cationic channel TRPML1 (also called mucolipin-1) and lysosomal calcium dyshomeostasis in the pathogenesis of amyotrophic lateral sclerosis/Parkinson–dementia complex [34,36,37]. This evidence concerns the gene MCOLN1 and amyotrophic lateral sclerosis.