In conclusion, we demonstrated that the SARS-CoV-2 virus uses cell entry mechanisms that cause NLRP-3 inflammasome activation, as well as Inflammasome activity and pyroptosis as a consequence of its activation covering the beginning of the process with cell infection, second signal with mitochondrial dysregulation NF-κB pathway modulation up until its final products as IL-1β and IL-18 as well as CASP1, we also differentiated the pyroptotic cell death process from other processes by measuring GDSMD and CASP9. The gene discussed is NFKB1; the disease is infection.