Pyroptosis is an inflammasome-dependent process, it is marked by CASP1-mediated GSDM-D cleavage and subsequent membrane pore formation [17,31], we observed that CASP1 was significantly more expressed in the COVID-19 group (p < 0.0001), while GSDM-D was significantly less expressed in the COVID-19 group (p < 0.0005). Here, GSDMD is linked to COVID-19.