IL-1β and IL-18 are direct results of inflammasome activation [28], our analysis showed that they were increased in the COVID-19 group when compared to the control (p < 0.0005) group and that IL-18 was increased in the COVID-19 group even when compared to the H1N1 group (p < 0.0001). The gene discussed is IL1B; the disease is COVID-19.