In this paper, we test a possible mechanism for the SARS-CoV-2 pathology through the observation of inflammasome complex activation markers (TLR4; ACE2; IL-1β; IL-18; NF-κB; ASC; NLRP-3 (or NALP); CASP1; CASP9; GDSM-D; NOX4; TNF-α) in post-mortem lung biopsies from patients that died from COVID-19 and compare them to samples from patients that died from non-acute pulmonary death causes and patients that died of the H1N1pdm09. This evidence concerns the gene CASP9 and COVID-19.