SPP1 and posterior cortical atrophy: Other highly expressed DEGs with known implications for PCa include FOCX2, which is highly expressed in BM PCa and co-occurs with an EMT phenotype [28], the cell adhesion molecule SPP1 encoding osteopontin [29,30], and Pentraxin-3 (PTX3) that has emerged as a predictive marker for a high risk of PCa development [31,32].