Based on the information described above, the current study was aimed at exploring, for the first time, the presence of the entire SST/CORT/SSTRs system in PCa, and to perform a parallel comparison of the in vitro effects of SST and CORT peptides on different normal-prostate and prostate tumor (PCa and CRPC) cell models, in order to design new diagnostic, prognostic, and therapeutic approaches that could impact the management of PCa, especially CRPC. This evidence concerns the gene CORT and prostate neoplasm.