SST and neoplasm: In this work, we observed that the treatment with SST and CORT peptides was able to reduce different key tumor parameters linked to tumor growth and metastasis (i.e., proliferation, migration, and colonies formation) only in AI-PCa cells (22Rv1 and PC-3 cells, two representative models of CRPC pathology), but not in normal prostate and AD-PCa cells, suggesting a potential and specific antitumor capacity of these peptides in the most aggressive phenotype of PCa.