However, our results have particular relevance because, to the best of our knowledge, this is the first evidence demonstrating a potential autocrine/paracrine regulatory function for endogenous CORT in cancer cells, which might be functionally linked to the expression of the dominant receptors expressed in PCa cells (i.e., SSTR1, SSTR2 and SSTR5). The gene discussed is SSTR5; the disease is cancer.