All these results suggest a causal link between dysregulation of endogenous CORT expression and PCa progression/aggressiveness and, therefore, that endogenous CORT may play a significant autocrine/paracrine pathophysiological role in AI-PCa cells, being its expression functionally linked to the dominant SSTR-subtypes expressed in PCa tissues. The gene discussed is CORT; the disease is posterior cortical atrophy.