Specifically, we found that SST and CORT could exert their antitumor actions in AI-PCa cells through the modulation of AKT, JNK, MKI67, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKND, MMP3, MMP9, MMP10, CDH2, EGF, EZH2, C-MYC, PTEN, and VEGFR levels. Here, CDK2 is linked to posterior cortical atrophy.