SSTR5 and posterior cortical atrophy: When viewing the results of Figure 3A,B together, it might be suggested that: (1) 22Rv1 and PC-3 were appropriate PCa cell models to perform the functional assays presented in this study (i.e., similar expression profile between AI-PCa cell models and human PCa tissues); and (2) human PCa might be sensitive to the actions of SST and CORT peptides as well as to different SSAs [first generation (octreotide; with high-affinity binding to SSTR2 and SSTR5) but specially to second generation (Pasireotide; a multireceptor-targeted SST with high affinity for SSTR1, SSTR2, SSTR3, and SSTR5)].