In fact, we have recently demonstrated that certain components of the SST system, especially some SSTR-subtypes [SSTR1-5, encoded by the somatostatin receptor 1–5 genes (SSTR1-5)], are dysregulated in PCa tissues and cells, wherein they play a relevant role in the pathophysiology of this disease [18,19,20]. This evidence concerns the gene SSTR1 and posterior cortical atrophy.