Moreover, in a viral infection-induced mouse model of SS-like sialadenitis, IL-22 deficiency leads to impaired B cell accumulation and tertiary lymphoid organ (TLO) formation within salivary glands and reduced autoantibody production, with the effect associated with defective upregulation of chemokines CXCL12 and-13 in salivary gland tissue cells in the TLOs [27]. This evidence concerns the gene IL22 and viral infectious disease.