NOS2 and Alzheimer disease: Increased proliferation [82,83] and expression of inflammatory markers including CD36, CD14, CD11c, MHC-II, and iNOS [84,85], as well as indicators of the M1 phenotype (such as IL-1, MCP-1, MIP-1, IL-1, TNF, and IL-6), and chemokine receptors are all signs of activated microglia in AD (e.g., CCR3, CCR5).