FTH1 might function as a tumor suppressor or as an oncogene; indeed, FTH1 knockdown reduces, both in vivo and in vitro, melanoma cell proliferation [22] and may modulate the MHC class I molecules expression leading to NK cells activation [23] while in the erythroleukemia K562 cell line determines an increased expression of a specific set of onco-miRNAs [24], activation of H19/miR-675 axis [25] and severe protein misfolding [26]. This evidence concerns the gene FTH1 and melanoma.