Macropinocytosis is induced by the activation of various receptors, such as the epidermal growth factor receptor (EGFR), which is highly expressed in tumour cells, such as human epidermal cancer A431 and the chemokine receptor CXCR4 [253,281,282,283,284,285,286,287,288,289,290,291,292,293,294,295,296,297]. The gene discussed is EGFR; the disease is neoplasm.