After being fed a high-cholesterol high-fat diet (1.5% cholesterol and 15% fat) for 4 months, ApoC3 knockout (ApoC3−/−) hamsters displayed an anti-atherogenic lipid profile and exhibited less atherosclerotic lesions in both abdominal and thoracic arteries, like humans; this data suggested that ApoC3 was a potential therapeutic target for the treatment of atherosclerosis [49]. The gene discussed is APOC3; the disease is atherosclerosis.