Furthermore, sphingolipid inhibitor d-PDMP (d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol, a glycosphingolipid inhibitor), has been reported to reduce lipid uptake and vascular inflammation and to protect against atherosclerosis in ApoE−/− mice [91]. The gene discussed is APOE; the disease is atherosclerosis.