One of them demonstrated that the number of SPB and PVC correlated with hs-cTnT and NT-proBNP levels [21], and another showed that a concentration of NT-proBNP in serum >287 pg/mL has a sensitivity of 55% and a specificity of 93% in predicting the occurrence of complex ventricular arrhythmias on a Holter monitor [49]. This evidence concerns the gene NPPB and Ventricular arrhythmia.