POMC and SATB2 associated disorder: Although the detailed mechanism by which IH affects the appetite regulation in patients with SAS has not been fully clarified, we previously investigated the effect of IH on the expression(s) of major appetite-regulating neuropeptide and receptor genes, such as POMC, CART, GAL, GALP, GHRL, QRFP, AGRP, NPY, and MC4R, using human neuronal cells (NB-1, SH-SY5Y, and SK-N-SH) and an in vitro IH system.