REN and hypertensive disorder: Taken together, IH upregulates the mRNA levels of Ren and Cd38 in JG cells via the downregulation of miR-203-mediated mRNA degradation and the mRNA levels of DBH and PNMT in neuroblastoma cells via the inhibition of miR-375-mediated mRNA degradation, which may contribute to hypertension (Figure 3).