With respect to insulin resistance due to IH in human hepatocytes, Uchiyama et al. revealed that IH stress upregulates the levels of SELENOP, which encodes selenoprotein P, a hepatokine responsible for insulin resistance, and upregulates the levels of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP), which encodes HIP/PAP, a type III Reg family member, to proliferate the hepatocytes, through the downregulation of miR-203, leading to the proliferation of liver cells with high levels of SELENOP mRNA [17]. Here, SELENOP is linked to Insulin resistance.