In contrast, although the isoflavones in the soy products may be beneficial for heart disease, the lectins however, are unlikely to be effective for preventing heart disease [38], as we noticed that gene expression of endothelin-1 (EDN1), a potent vasoconstrictor, was upregulated and the insulin receptor (INSR) was downregulated by LPS or LEC. Here, EDN1 is linked to heart disorder.