BACE1 and Alzheimer disease: Therefore, the chemical structure of compound 3r and 3t results are interesting with respect to the pharmacophores to design a multitarget compound for AD targeting AChE, BACE1 and Aβ1-42 anti-aggregation, as it has been described that a linker between two aromatics rings containing a hydroxyethylene or hydroxyethylamine to form a hydrogen bond with the aspartic dyad in the catalytic site of BACE1 is necessary.