SDHA and Cachexia: Additionally, deletion of the fission-related DRP1 gene led to skeletal muscle atrophy and degeneration [35], whereas disruption of mitochondrial homeostasis in cachexia resulted in decreased mitochondrial function and related proteins [115,116,117], such as CYTC, succinate dehydrogenase complex flavoprotein subunit A (SDHA), OXPHOS complex IV, transcription factor A, mitochondrial (TFAM), translocase of outer mitochondrial membrane 20 (TOMM20), and mtDNA content [116,118,119,120].