In 2005, Neve and colleagues reported KLF11 as a causative gene for MODY7 with the identification of two KLF11 variants, p.Ala347Ser and p.Thr220Met, in individuals diagnosed with early-onset T2DM, which were shown to significantly impair the transcriptional activity of KLF11. The gene discussed is KLF11; the disease is type 2 diabetes mellitus.