Indeed, several research groups have reported an increase in the secretion of the vascular endothelial growth factor (VEGF), hypoxia-inducible transcription factor (HIF)-1α, fibroblast growth factor (FGF), osteopontin (OPN) or angiopoietin (Ang)-1 by myeloma cells. The gene discussed is VEGFA; the disease is plasma cell myeloma.