Among the metabolic enzymes with abnormal expression, the expression levels of the genes related to glycolysis (HK1, GPI, ALDOA, and ENO1; Figure 6A), the HPB (GFPT1, GNPNAT1, PGM3, and UAP1; Figure 6B), and the TCA cycle (PDHB, IDH2, FH, and SDHA; Figure 6C) were significantly increased in the breast cancer tissues compared to the corresponding adjacent normal tissues. The gene discussed is GPI; the disease is breast cancer.