We investigated the effect of the expression of these genes on the overall survival of the patients with breast cancer, and the results revealed that the high expression levels of HK1 (crude hazard ratio [CHR] = 2.80; 95% CI = 1.34–5.84, p = 0.006), ENO1 (CHR = 2.21; 95% CI = 1.39–3.52, p = 0.001), IDH2 (CHR = 1.7; 95% CI = 1.05–2.73, p = 0.029), PDHB (CHR = 0.56; 95% CI = 0.35–0.89, p = 0.015), and SDHA (CHR = 1.70; 95% CI = 1.05–2.73, p = 0.029) were significantly associated with shorter overall survival in the patients with breast cancer (Table S9 and Figure 7A). The gene discussed is HK1; the disease is breast cancer.