Along with lamin dysfunction [29,30,31] and cytoplasmic Tau pathology [37,38,39], the aberrant chromatin structure of pyramidal AD neurons in humans, rodents, and Drosophila AD models is characterized by the dysregulated expression of epigenetic markers H4K20me3 [40], H3K9me3 [41] H3K9me2 [42], and H3K9ac [39]. The gene discussed is MAPT; the disease is Alzheimer disease.