Concerning FTLD, a decreased expression of a mitochondrial module in frontal cortex tissue from FTD-TDP patients was reported [48], and a very recent study has shown that in brains of FTD patients carrying different GRN mutations, mitochondrial dysregulation is detected in neurons at variance with MAPT mutations carriers, where other cellular processes are affected [49]. Here, MAPT is linked to frontotemporal dementia.