Intestinal epithelial injury during sepsis was reduced with the non-selective SphK inhibitor N,N-dimethylsphingosine (DMS) and SphK1 was shown to be involved in nucleotide-binding oligomerization domain-like receptor containing pyrin domain 3 (NLRP3) inflammasome activation and subsequent lung injury in mice suffering from polymicrobial sepsis [26,27]. The gene discussed is SPHK1; the disease is Sepsis.