ACLY and neoplasm: Currently, it is known that one of the key regulators of lipogenesis in tumor cells is proteins that bind sterol regulatory elements (SREBP), which in turn transcriptomically activate such enzymes as ATP-citrate lyase (ACLY), acetyl-CoA carboxylase (ACC), fatty acid synthase (FASN), and acyl-CoA synthetase (ACS) [29].