FOLR1 and neoplasm: The overexpression of FRα in 90–95% of patients with EOC [14,15] and the absence of FRα on normal cells, reflecting a high tumor-to-background ratio (TBR), offer an excellent opportunity to apply near-infrared imaging in patients with ovarian cancer for the purpose of upgraded intraoperative tumor detection and the radical excision of the malignant tissue, thereby improving ovarian cancer outcomes [24].