Previous reports have demonstrated that stimulation with nicotine could induce proliferation in a variety of in vitro cell culture models, an effect that could be abrogated by nAChR antagonists, such as the α7 antagonist α-bungarotoxin (α-BTX), which blocks the proliferative effects of nicotine, pointing to α7-nAChR as a potential target for cancer therapy [22,30]. This evidence concerns the gene CHRNA7 and cancer.