In addition, the chromosomal translocation t (4; 22) (q31; q12) occurring in the genomic locus of SMARCA5, which generates an EWSR1–SMARCA5 fusion protein via the in-frame fusion of EWSR1 to the last exons of SMARCA5 in extraskeletal Ewing sarcoma/PNET, was identified as having tumorigenic potential [55]. Here, SMARCA5 is linked to primitive neuroectodermal tumor.