CHD7 and tarsal-carpal coalition syndrome: Moreover, genomic aberration was also observed in other CHD genes, such as CHD6 mutation in transitional cell carcinoma (TCC) [74], high mutation rates of CHD7 and CHD8 in CpG islands of methylator phenotype 1 subgroups of colorectal carcinomas (CRCs) [75], and in the recurrent rearrangement of CHD7 in tobacco-smoking small-cell lung cancer patients [76].