Chromatin-remodeling factor ARID2, which belongs to the PBAF complex in the SWI/SNF subfamily, was found to be expressed at a lower level in metastatic hepatocellular carcinoma tissues and to suppress HCC metastasis via the DNMT1–Snail axis, indicating the great therapeutic potential of targeting the DNMT1–Snail axis in ARID2-deficient HCC [147]. Here, DNMT1 is linked to hepatocellular carcinoma.