A CRISPR-Cas9 screen analysis found that ARID2, BRD7, and PBRM1, components of the PBAF complex, sensitized mouse melanoma cells to T-cell cytotoxicity, and PBRM1-deficient murine melanomas were found to be infiltrated by more cytotoxic T cells [163]. The gene discussed is PBRM1; the disease is melanoma.