Indeed, patients with von Willebrand disease present not only coagulation, but also platelet disorders, as demonstrated by the markedly impaired thrombin generation time measured in the plasma of type 3 von Willebrand disease patients, which lack vWF in plasma, platelets, and endothelial cells, whereas this is not the case when thrombin generation time is measured in the presence of normal platelets [36]. This evidence concerns the gene VWF and Von Willebrand disease.