ABCG2 and cancer: Our data show that hydroxygenkwanin did not significantly alter the protein expression of ABCG2 in NCI-H460/MX20 (Figure 5A) or A549-Bec150 (Figure 5B) cancer cells, thus suggesting that it restores the chemosensitivity of these multidrug-resistant cancer cells by attenuating the function of ABCG2.